Treatment-Resistant Depression · Colorado
The Best Treatment-Resistant Depression Clinics in Colorado: 2026 Review
By the Colorado Mental Health Review editorial team · Reviewed against our methodology · Updated October 2026
Treatment-resistant depression has a working definition — depression that has not responded adequately to two or more antidepressants — and a specific set of treatments built for it: TMS, SPRAVATO®, and ketamine therapy, usually alongside a medication review. A "treatment-resistant depression clinic" is a practice that can deliver all of those under one psychiatrist. This statewide review ranks Colorado practices on exactly that — physician leadership, whether all three interventional options are available in one practice, insurance and TRICARE access, and reach by video and in person. Providers sharing ownership with this publication are disclosed at the listing and on our disclosure page.
1. TMS Therapy Centers Colorado
https://tmstherapycenterscolorado.com/
TMS Therapy Centers Colorado shares ownership with this publication. See our full disclosure.
Aurora
Founded by board-certified psychiatrist Dr. William Kromka, MD, specifically for patients whose antidepressants have not been enough: FDA-cleared TMS and accelerated iTBS, certified SPRAVATO®, physician-supervised ketamine therapy, and a medication review are all available in one clinic, with video evaluations anywhere in Colorado and accelerated scheduling for patients who travel in. Most major insurance including Medicare and TRICARE. Phone: 720-500-7873.
Visit website ↗2. Denver TMS Therapy
https://denvertmstherapy.com/
Denver TMS Therapy shares ownership with this publication. See our full disclosure.
Denver, LoHi
Central Denver's physician-led clinic for depression that has not responded to medication: a psychiatrist evaluates every patient, and TMS, accelerated iTBS, SPRAVATO®, ketamine therapy, and medication management are under one roof so the plan can change without changing clinics. TRICARE-authorized; most commercial plans. Phone: (720) 214-2770.
Visit website ↗3. Denver Ketamine Clinic
https://denverketamineclinic.com/
Denver Ketamine Clinic shares ownership with this publication. See our full disclosure.
Denver, Washington Park West
Built around the two ketamine-based pathways for treatment-resistant depression — FDA-approved SPRAVATO® and off-label ketamine therapy — under one psychiatrist, with the difference in approval, coverage, and cost explained before any decision, and TMS available in the same clinic. Founded by Dr. Kromka. Phone: (720) 221-8560.
Visit website ↗4. Bluebird TMS
https://bluebirdtms.com/
Bluebird TMS shares ownership with this publication. See our full disclosure.
Greenwood Village, Denver Tech Center
The south-metro option for treatment-resistant depression built around a working schedule: TMS, accelerated iTBS, SPRAVATO®, ketamine therapy, and medication management in one Tech Center clinic, brief sessions before work or at lunch, video evaluations so treatment starts the same week. TRICARE-authorized. Phone: (720) 716-8469.
Visit website ↗5. TMS Boulder
https://tmsboulder.com/
TMS Boulder shares ownership with this publication. See our full disclosure.
Boulder, downtown
Boulder County's physician-led clinic for depression that has not responded to medication — TMS, accelerated iTBS, SPRAVATO®, ketamine therapy, and medication management one block from Pearl Street, with video evaluations for Louisville, Lafayette, Longmont, and the mountain towns. Founded by Dr. Kromka. Phone: (720) 833-4948.
Visit website ↗6. Axis Integrated Mental Health
https://axismh.com/
Aurora, Westminster, DTC, Louisville
A four-clinic metro practice that treats treatment-resistant depression with deep TMS and SPRAVATO® inside a psychiatry and therapy model.
Visit website ↗7. Colorado Psychiatry Solutions
https://psychsolutions.health/
Colorado Springs and Monument
Three Pikes Peak locations offering psychiatry, therapy, TMS including accelerated protocols, and ketamine for depression that has not responded to medication.
Visit website ↗8. Klarisana
https://klarisana.com/
Denver
A dedicated ketamine-treatment organization, including SPRAVATO®, with institutional experience in treatment-resistant mood conditions.
Visit website ↗9. Psychiatric Services of the Rockies
https://www.psychiatricservicesoftherockies.com/
Fort Collins
A psychiatrist-led Northern Colorado practice with TMS and SPRAVATO® in-office and statewide telemedicine.
Visit website ↗10. Denver Wellness Associates
https://denverwellnessassociates.com/
Denver metro
A multi-location psychiatry group offering TMS and SPRAVATO® within full psychiatric services.
Visit website ↗11. University of Colorado Department of Psychiatry
https://medschool.cuanschutz.edu/psychiatry
Aurora
The academic psychiatry department of the state's medical school, with specialty programs for difficult-to-treat depression.
Visit website ↗
Common questions
What counts as treatment-resistant depression?
Most clinicians and insurers use the working definition of major depression that has not responded adequately to two or more antidepressant trials at adequate dose and duration. That history is also what most plans require before covering TMS or SPRAVATO®.
What is a treatment-resistant depression clinic?
A practice where a psychiatrist evaluates you and the treatments built for this stage — TMS, SPRAVATO®, ketamine therapy, and a medication review — are available in the same place, so non-response to one becomes a next conversation rather than a referral.
Is there a treatment-resistant depression specialist near me?
The practices at the top of this list evaluate patients by video anywhere in Colorado and treat in person in Aurora, Denver, Greenwood Village, and Boulder; regional practices listed below serve Colorado Springs and Fort Collins.
Where are the best treatment-resistant depression clinics near me in Colorado?
"Near me" returns whichever provider is closest; this list ranks the providers serving Colorado on the criteria that change outcomes — physician leadership, breadth of treatment in one practice, insurance access, and how fast you can be seen — with the practices that meet all of them listed first. Use the entries above, then confirm the closest one that fits.
Who are the top treatment-resistant depression clinics in Colorado?
The practices at the top of this list, in the order shown. Each entry explains why it ranks where it does and links to the provider's own site. Practices sharing ownership with this publication are disclosed at the listing.
How do I choose among the treatment-resistant depression clinics in Colorado?
Match the provider to your stage of treatment first, confirm your plan is accepted, ask whether the evaluation can be done by video, and prefer a practice that can offer the next treatment itself if the first one is not enough.
How to choose among them
Confirm the practice can offer all three interventional treatments, not one; confirm a psychiatrist — not a technician-only model — oversees the plan; confirm your plan is accepted and authorization is handled for you; and ask for a video evaluation so the first appointment is this week.